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Archives

Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex

Wang J, Wang J, Shin BS, Kim JR, Dever TE, Puglisi JD, Fernández IS. Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex. Nat Commun. 2020 Oct 6;11(1):5003. doi: 10.1038/s41467-020-18829-3. PMID: 33024099.
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Advances in understanding the initiation of HIV-1 reverse transcription

Krupkin M, Jackson LN, Ha B, Puglisi EV. Advances in understanding the initiation of HIV-1 reverse transcription. Curr Opin Struct Biol. 2020 Dec;65:175-183. doi: 10.1016/j.sbi.2020.07.005. Epub 2020 Sep 8. PMID: 32916568.
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Distinct Conformational States Underlie Pausing during Initiation of HIV-1 Reverse Transcription

Larsen KP, Choi J, Jackson LN, Kappel K, Zhang J, Ha B, Chen DH, Puglisi EV. Distinct Conformational States Underlie Pausing during Initiation of HIV-1 Reverse Transcription. J Mol Biol. 2020 Jul 24;432(16):4499-4522. doi: 10.1016/j.jmb.2020.06.003. Epub 2020 Jun 6. PMID: […]
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A memory of eS25 loss drives resistance phenotypes

Johnson AG, Flynn RA, Lapointe CP, Ooi YS, Zhao ML, Richards CM, Qiao W, Yamada SB, Couthouis J, Gitler AD, Carette JE, Puglisi JD. A memory of eS25 loss drives resistance phenotypes. Nucleic Acids Res. 2020 Jul 27;48(13):7279-7297. doi: 10.1093/nar/gkaa444. […]
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Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5′ mRNA Stem-Loop and Enhanced Drop-off

O’Loughlin S, Capece MC, Klimova M, Wills NM, Coakley A, Samatova E, O’Connor PBF, Loughran G, Weissman JS, Baranov PV, Rodnina MV, Puglisi JD, Atkins JF. Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of […]
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The energy landscape of -1 ribosomal frameshifting

Choi J, O’Loughlin S, Atkins JF, Puglisi JD. The energy landscape of -1 ribosomal frameshifting. Sci Adv. 2020 Jan 1;6(1):eaax6969. doi: 10.1126/sciadv.aax6969. eCollection 2020 Jan. PMID: 31911945.
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Dynamics of the context-specific translation arrest by chloramphenicol and linezolid

Choi J, Marks J, Zhang J, Chen DH, Wang J, Vázquez-Laslop N, Mankin AS, Puglisi JD. Dynamics of the context-specific translation arrest by chloramphenicol and linezolid. Nat Chem Biol. 2020 Mar;16(3):310-317. doi: 10.1038/s41589-019-0423-2. Epub 2019 Dec 16. PMID: 31844301.
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