Research Highlights

The groups of Jody Puglisi and Elisabetta Viani Puglisi investigate the physical basis for RNA function in biology. We apply biochemical, structural and biophysical approaches to link three-dimensional structures of RNAs and their complexes with their dynamics.

Recent Publications

Jinfan Wang, Byung-Sik Shin, Carlos Alvarado, et al. Rapid 40S scanning and its regulation by mRNA structure during eukaryotic translation initiation. Cell. 2022 Nov 23. doi: 10.1016/j.cell.2022.10.005. PMID: 36334590.

Arjun Prabhakar, Natalie Krahn, Jingji Zhang, et al. Uncovering translation roadblocks during the development of a synthetic tRNA. Nucleic Acids Res. 2022 Oct 14;50(18):10201-10211. doi: 10.1093/nar/gkac576. PMID: 35882385.

Christopher P. Lapointe, Rosslyn Grosely, Masaaki Sokabe, et al. eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. Nature. 2022 Jun 22. doi: 10.1038/s41586-022-04858-z. PMID: 35732735.

Lab News

Jinfan’s recently published paper about the mechanism of eukaryotic scanning has been highlighted in Molecular Cell.

Alum Albert Tsai (PhD Applied Physics) has been selected as the 2022 ATIP-Avenir laureate as he starts his research lab at CRBM in Montpellier, France. Congrats, Albert!

Jinfan’s work on the mechanism of eukaryotic scanning is now published in Cell! Read about translation initiation and its regulation by RNA structure and near-cognate start codons here.

Betty has successfully defended her thesis “Investigations into viral RNA replication”. Congratulations Dr. Ha!