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Research Highlights

The groups of Jody Puglisi and Elisabetta Viani Puglisi investigate the physical basis for RNA function in biology. We apply biochemical, structural and biophysical approaches to link three-dimensional structures of RNAs and their complexes with their dynamics.

Recent Publications

Lawson MR, Lessen LN, Wang J, Prabhakar A, Corsepius NC, Green R, Puglisi JD. Mechanisms that ensure speed and fidelity in eukaryotic translation termination. Science. 2021 Aug 20;373(6557):876-882. doi: 10.1126/science.abi7801. PMID: 34413231.

Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV. High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs. Nat Commun. 2021 May 4;12(1):2500. doi: 10.1038/s41467-021-22628-9. PMID: 33947853.

Ieong KW, Indrisiunaite G, Prabhakar A, Puglisi JD, Ehrenberg M. N 6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors. Nucleic Acids Res. 2021 Mar 18;49(5):2684-2699. doi: 10.1093/nar/gkab033. PMID: 33561188.

Lab News

Mike has received the NIH Pathway to Independence Award (K99/R00) for his single-molecule studies of eukaryotic translation and mRNA decay. Congrats Mike!

Chris has received the 2022 Damon Runyon-Dale F. Frey Award for Breakthrough Scientists for his research on human translation initiation!

Jody has been selected as a Chan Zuckerberg Biohub Investigator in the 2021 cohort: https://www.czbiohub.org/investigator-competition-2021/

Chris has received the NIH Pathway to Independence Award (K99/R00) for his single-molecule and structural studies of human translation initiation. Congrats Chris!

Research Highlights

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Featured Publications

James J, Miller L, Runnstein R. Sodales ut Velit at Ornare Rhoncus Sem. Pubmag 12:2606-2616, 2018.

Lanova CJ, Clark A, Mihiro Y, James J. Aliquam Faucibus ex Quis Ipsum Bibendum Sollicitudin. MedJourn, In Press. PMID: 309672555

Integer TE, Veget N, Augue PA, Vulputate HI, Nelson D. Phasellus Lobortis mi in Arcu Lobortis id Placerat Velit Aliquam Pellentesque Dignissim sed Enim non Efficitur. MedJourn, In Press.

Featured News